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  1. Megan Carey
    Neural Circuits and Behavior


    Eugenia Chiappe
    Sensorimotor Integration


    Rui Costa
    Neurobiology of Action


    Bruno Costa-Silva
    Systems Oncology


    Gonzalo de Polavieja
    Collective Behavior


    Susana Lima
    Neuroethology


    Christian Machens
    Theoretical Neuroscience


    Zachary Mainen
    Systems Neuroscience


    Marta Moita
    Behavioral Neuroscience


    Eduardo Moreno
    Cell Fitness


    Michael Orger
    Vision to Action


    Joe Paton
    Learning


    Leopoldo Petreanu
    Cortical Circuits


    Alfonso Renart
    Circuit Dynamics & Computation


    Christa Rhiner
    Stem cells and regeneration


    Carlos Ribeiro
    Behavior and Metabolism


    Adriana Sánchez Danés
    Cancer and Stem Cell Biology


    Noam Shemesh
    Preclinical MRI


    Maria Luísa Vasconcelos
    Innate Behavior


    Henrique Veiga-Fernandes
    Immunophysiology


  1. Cancer and Stem Cell Biology



    Most tumours are heterogeneous at the cellular and (epi)genetic levels. This heterogeneity has been proposed to be responsible for tumour progression, metastasis and resistance to therapy. Our goal is to understand the contribution of the different tumour cell populations and genetic alterations to cancer progression and response to therapy. We do that by combining genetic lineage tracing, clonal analysis, imaging techniques, tumour organoid cultures and functional experiments in vivo and in vitro. We use the most frequent human cancer – basal cell carcinoma – and one of the most common pediatric cancers – medulloblastoma – as the models for our studies. Both types of cancer arise upon the constitutive activation of the Hedgehog signalling pathway.

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