Adriano Aguzzi (Clinical Seminar)
Date: December 05, 2019. 14:00
Location: CCU Seminar Room
Title: Drivers of neurotoxicity in prion diseases
Affiliation: Director, Institute of Neuropathology, University of Zurich.
Many proteins can self-assemble into highly-ordered fibrillary aggregates called amyloids, which are responsible for a number of human diseases including Alzheimer’s, Parkinson’s and systemic amyloidoses. The mechanisms of amyloid assembly is relatively well-understood, yet the downstream events leading to toxicity are largely unknown. My lab studies these phenomena using prions, infectious self-replicating protein-only particles causing transmissible spongiform encephalopathies. In my seminar, I will discuss the molecular events underlying prion toxicity and highlight possible therapeutic strategies.